Human Alpha B Crystallin / CRYAB ELISA Kit

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SKU:
HUFI00546
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P02511
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
CRYalphaB, Crystallin Alpha B, CRYAB, CRYA2, CTPP2, HSPB5, alpha B crystallin, alpha, B-crystallin, alpha-crystallin B chain, alpha crystallin B chain, Heat shock protein beta-5, heat-shock 20 kD like-protein, Renal carcinoma antigen NY-REN-27, Rosen
Reactivity:
Human
Research Area:
Cell Biology

Description

Human Alpha B Crystallin / CRYAB ELISA

Many neurological diseases are associated with elevated alpha-B crystallin expression (CRYAB), and a missense mutation is co-segregated in a family with a desmin-related myopathy. Myofibrillar, 2, and cardiomyopathy, dilated 1Ii are examples of additional CRYAB (Crystallin alpha-B) related diseases. Protein homodimerization activity and microtubule-binding are among the GO annotations associated with CRYAB. LOC102724652 is a paralog of CRYAB. Alpha, beta, and gamma lens crystallins are the three families of mammalian lens crystalline. Alpha crystallins are made up of two subtypes: alpha-A (acidic) and alpha-B (basic). Alpha-A expression is restricted to the lens, while alpha-B is expressed throughout the body. Heat shock can stimulate alpha crystallins, which are part of the small heat shock protein (HSP20) family. Alpha crystallins are molecular chaperones but they do not function as traditional molecular chaperones; instead, they maintain proteins in large soluble aggregates. Each aggregate includes 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio. Additional functions of alpha crystallins' includes autokinase activity and involvement in the intracellular structure. Based on its capacity to execute mechanistically distinct activities, Alpha B Crystallin has been termed a moonlighting protein.

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