Human AHA1 Recombinant Protein (RPPB5192)
- SKU:
- RPPB5192
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95433
Description
| Product Name: | Human AHA1 Recombinant Protein |
| Product Code: | RPPB5192 |
| Size: | 50µg |
| Species: | Human |
| Target: | AHA1 |
| Synonyms: | AHSA1, ACA1, p38, C14orf3, Activator of HSP90 ATPase-1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The AHA1 protein solution contains 20mM Tris-HCI buffer (pH 8.0) and 2mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MATNVNNWHW TERDASNWST DKLKTLFLAV QVQNEEGKCE VTEVSKLDGE ASINNRKGKL IFFYEWSVKL NWTGTSKSGV QYKGHVEIPN LSDENSVDEV EISVSLAKDE PDTNLVALMKEEGVKLLREA MGIYISTLKT EFTQGMILPT MNGESVDPVG QPALKTEERK AKPAPSKTQARPVGVKIPTC KITLKETFLT SPEELYRVFT TQELVQAFTH APATLEADRG GKFHMVDGNV SGEFTDLVPE KHIVMKWRFK SWPEGHFATI TLTFIDKNGE TELCMEGRGI PAPEEERTRQ GWQRYYFEGI KQTFGYGARL |
AHA1 is a cochaperone that stimulates hsp90 ATPase activity. AHSA1 binds the middle domain of Hsp90 (amino acid 272-627) and functions as an ATPase-activating protein that competes with p23 and other co-chaperones for Hsp90 binding.AHA1 affects a step in the endoplasmic reticulum to golgi trafficking.
AHA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 320 amino acids (19-337) and having a molecular mass of 36.1 kDa.
| UniProt Protein Function: | AHSA1: Cochaperone that stimulates HSP90 ATPase activity. May affect a step in the endoplasmic reticulum to Golgi trafficking. Belongs to the AHA1 family. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 14q24 Cellular Component: cytoplasm Molecular Function:ATPase activator activity; chaperone binding; protein binding |
| UniProt Code: | O95433 |
| NCBI GenInfo Identifier: | 13124003 |
| NCBI Gene ID: | 10598 |
| NCBI Accession: | O95433.1 |
| UniProt Secondary Accession: | O95433,Q96IL6, Q9P060, B2R9L2, B4DUR9, |
| UniProt Related Accession: | O95433 |
| Molecular Weight: | 32,340 Da |
| NCBI Full Name: | Activator of 90 kDa heat shock protein ATPase homolog 1 |
| NCBI Synonym Full Names: | activator of Hsp90 ATPase activity 1 |
| NCBI Official Symbol: | AHSA1�� |
| NCBI Official Synonym Symbols: | p38; AHA1; hAha1; C14orf3�� |
| NCBI Protein Information: | activator of 90 kDa heat shock protein ATPase homolog 1 |
| UniProt Protein Name: | Activator of 90 kDa heat shock protein ATPase homolog 1 |
| UniProt Synonym Protein Names: | p38 |
| Protein Family: | Activator of 90 kDa heat shock protein ATPase |
| UniProt Gene Name: | AHSA1�� |
| UniProt Entry Name: | AHSA1_HUMAN |
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