Growth Factors & Cytokines Recombinant Proteins

Human ACVR2A Recombinant Protein (RPPB0011)

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SKU:
RPPB0011
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P27037
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human ACVR2A Recombinant Protein
Product Code:RPPB0011
Size:10µg
Species:Human
Target:ACVR2A
Synonyms:ACVR2A, ACTRIIA, ACTR-IIA,
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ACVR2A protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:AILGRSETQE CLFFNANWEK DRTNQTGVEP CYGDKDKRRH CFATWKNISG SIEIVKQGCW LDDINCYDRT DCVEKKDSPE VYFCCCEGNM CNEKFSYFPE MEVTQPTSNP VTPKPPLEHH HHHH

ACVR2A takes part in various biological processes including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, carcinogenesis, and inflammation. ACVR2A which is a receptor for Actv�A, Actv B and inhibin A mediates induction of adipogenesis by GDF6.

ACVR2A Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 124 amino acids (20-135a.a.) and having a molecular mass of 14.4kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).ACVR2A is fused to 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.
UniProt Protein Details:

Protein type:Membrane protein, integral; Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Motility/polarity/chemotaxis; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 2q22.3

Cellular Component: cell surface; integral to plasma membrane; cytoplasm; plasma membrane; receptor complex

Molecular Function:transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; activin receptor activity; protein self-association; growth factor binding; metal ion binding; activin binding; coreceptor activity; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity; PDZ domain binding

Biological Process: embryonic skeletal development; positive regulation of erythrocyte differentiation; regulation of BMP signaling pathway; activin receptor signaling pathway; Sertoli cell proliferation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of osteoblast differentiation; positive regulation of activin receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; mesoderm development; spermatogenesis; sperm ejaculation; regulation of nitric-oxide synthase activity; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; penile erection

NCBI Summary:This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
UniProt Code:P27037
NCBI GenInfo Identifier:114722
NCBI Gene ID:92
NCBI Accession:P27037.1
UniProt Secondary Accession:P27037,Q53TH4, Q6NWV2, Q92474, B2RAB8, B4DWQ2, D3DP85
UniProt Related Accession:P27037
Molecular Weight:513
NCBI Full Name:Activin receptor type-2A
NCBI Synonym Full Names:activin A receptor, type IIA
NCBI Official Symbol:ACVR2A��
NCBI Official Synonym Symbols:ACVR2; ACTRII��
NCBI Protein Information:activin receptor type-2A
UniProt Protein Name:Activin receptor type-2A
UniProt Synonym Protein Names:Activin receptor type IIA; ACTR-IIA; ACTRIIA
Protein Family:Activin receptor
UniProt Gene Name:ACVR2A��
UniProt Entry Name:AVR2A_HUMAN
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