Immune Checkpoint Recombinant Proteins
Human 4-1BB Ligand Recombinant Protein (mFc-His Tag) (HDPT0045)
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- SKU:
- HDPT0045
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immune Checkpoint
Description
Human 4-1BB Ligand Recombinant Protein (mFc-His Tag)
| Description: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. |
| Product name: | Human 4-1BB Ligand Recombinant Protein (mFc-His Tag) |
| Synonyms: | 4-1BB Ligand,TNFSF9,CD137L |
| Type: | protein |
| Size: | 50 µg |
| Name: | 4-1BB Ligand |
| Origin: | Human |
| Source: | HEK293 |
| Protein Type: | Recombinant |
| Application: | Contact Technical Support |
| Purity: | > 95% |
| Purification: | affinity purification |
| Format: | Lyophilized |
| Conjugate: | N-Mouse Fc and C-6×His tag |
| Storage: | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| Usage: | Research use only |
| Buffer: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Reconstitution: | Reconstitute with deionized water |
| Sequence: | mFc（Pro99-Lys330）+4-1BB Ligand（Pro52-Glu254）+6×His |
| Gene ID: | 8744 |
| Uniprot: | P41273 |
| Molecular Weight: | 49.8 kDa |
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