Immune Checkpoint Recombinant Proteins

Human 4-1BB Ligand Recombinant Protein (mFc-His Tag) (HDPT0045)

(No reviews yet) Write a Review
SKU:
HDPT0045
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human 4-1BB Ligand Recombinant Protein (mFc-His Tag)

Description:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Product name:Human 4-1BB Ligand Recombinant Protein (mFc-His Tag)
Synonyms:4-1BB Ligand,TNFSF9,CD137L
Type:protein
Size:50 µg
Name:4-1BB Ligand
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:> 95%
Purification:affinity purification
Format:Lyophilized
Conjugate:N-Mouse Fc and C-6×His tag
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:mFc(Pro99-Lys330)+4-1BB Ligand(Pro52-Glu254)+6×His
Gene ID:8744
Uniprot:P41273
Molecular Weight:49.8 kDa
View AllClose

0 Reviews

View AllClose