Description
 system_update_alt Datasheet 
| Product Name: | HTRA2 Antibody | 
| Product Sku: | CPAB0197 | 
| Size: | 5μg | 
| Host Species: | Mouse | 
| Immunogen: | Anti-human HTRA2 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human HTRA2 protein 134-458 amino acids purified from Ecoli. | 
| Clone: | PAT4G8AT. | 
| Reactivity: | Human | 
| Applications: | Western Blot, ELISA | 
| Purification Method: | HTRA2 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. | 
| Isotype: | IgG1 | 
| Background: | HtrA2 also called Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP)-binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death. | 
| Synonyms: | Serine protease HTRA2 mitochondrial, EC 3.4.21.108, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine proteinase OMI, Serine protease 25, OMI, PARK13, PRSS25. | 
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. | 
 
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