HLA-G Monoclonal Antibody
- SKU:
- CAB24425
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | HLA-G Monoclonal Antibody |
| Product Code: | CAB24425 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC63292 |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:5000-1:10000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T transfected with HLA-G |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HLA-G (NP_002118.1). |
| Sequence: | GYVDD TQFVR FDSDS ACPRM EPRAP WVEQE GPEYW EEETR NTKAH AQTDR MNLQT LRGYY NQSEA SSHTL QWMIG CDLGS DGRLL RGYEQ YAYDG KDYLA L |
| Synonyms: | MHC-G |
| Calculated MW: | 38kDa |
| Observed MW: | 30-40kDa |
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