HIF3A Antibody (PACO05029)
- SKU:
- PACO05029
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HIF3A Antibody (PACO05029) |
| Antibody SKU: | PACO05029 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human HIF-3 α . |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | Hypoxia-inducible factor 3-α; HIF-3-α; HIF3-α; Basic-helix-loop-helix-PAS protein MOP7; Class E basic helix-loop-helix protein 17; bHLHe17; HIF3-α-1; Inhibitory PAS domain protein; IPAS; Member of PAS protein 7; PAS domain-c |
| UniProt Protein Function: | HIF3A: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factor; Tumor suppressorChromosomal Location of Human Ortholog: 19q13.32Cellular Component: nucleoplasm; cytosolMolecular Function: protein dimerization activity; signal transducer activity; DNA binding; transcription coactivator activity; transcription factor activity; transcription corepressor activityBiological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q66K72 |
| NCBI GenInfo Identifier: | 326807022 |
| NCBI Gene ID: | 64344 |
| NCBI Accession: | NP_071907.4 |
| UniProt Secondary Accession: | Q66K72,Q58A43, Q66K72, Q8WXA1, Q96K34, Q9H7Z9, Q9HAI2 B0M185, B4DNA2, I6L988 |
| UniProt Related Accession: | Q66K72,Q9Y2N7 |
| Molecular Weight: | 64,359 Da |
| NCBI Full Name: | hypoxia-inducible factor 3-alpha isoform b |
| NCBI Synonym Full Names: | hypoxia inducible factor 3, alpha subunit |
| NCBI Official Symbol: | HIF3A |
| NCBI Official Synonym Symbols: | IPAS; MOP7; PASD7; HIF-3A; bHLHe17 |
| NCBI Protein Information: | hypoxia-inducible factor 3-alpha |
| UniProt Protein Name: | Hypoxia-inducible factor 3-alpha |
| UniProt Synonym Protein Names: | Basic-helix-loop-helix-PAS protein MOP7; Class E basic helix-loop-helix protein 17; bHLHe17; HIF3-alpha-1; Inhibitory PAS domain protein; IPAS; Member of PAS protein 7; PAS domain-containing protein 7 |
| Protein Family: | Hypoxia-inducible factor |
| UniProt Gene Name: | HIF3A |
| UniProt Entry Name: | HIF3A_HUMAN |
Related Products
Rat HIF3A(Hypoxia-inducible factor 3-alpha) ELISA Kit
OverviewProduct Name:Rat HIF3A(Hypoxia-inducible factor 3-alpha) ELISA KitProduct Code:AEFI00963Size:96TAlias:HIF3A, Hypoxia-inducible f
Human HIF3A(Hypoxia-inducible factor 3-alpha) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human TP53 antibody(p53 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost
eutC Antibody
Overview Product Name:eutC AntibodyProduct Code:PACO64709Size:50µLTarget Names:eutCSpecies Reactivity:Escherichia coli
EPHA10 Antibody
Overview Product Name:EPHA10 AntibodyProduct Code:PACO64693Size:50µLTarget Names:EPHA10Species Reactivity:HumanH
otsB Antibody
Overview Product Name:otsB AntibodyProduct Code:PACO64885Size:50µLTarget Names:otsBSpecies Reactivity:Escherichia coli
PCDHA8 Antibody
Overview Product Name:PCDHA8 AntibodyProduct Code:PACO64893Size:50µLTarget Names:PCDHA8Species Reactivity:HumanH