HEXA Polyclonal Antibody
- SKU:
- CAB21777
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | HEXA Polyclonal Antibody |
| Product Code: | CAB21777 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Lysosome |
This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA (NP_000511.2). |
| Sequence: | IPGLL TPCYS GSEPS GTFGP VNPSL NNTYE FMSTF FLEVS SVFPD FYLHL GGDEV DFTCW KSNPE IQDFM RKKGF GEDFK QLESF YIQTL LDIVS SYGKG YVVWQ EVFDN KVKIQ PDTII QVWRE DIPVN YMKEL ELVTK AGFRA LLSAP WYLNR ISYGP DWKDF YIVEP LAFEG TPEQK ALVIG GEACM WGEYV DNTNL VPRLW PRAGA VAERL WSNKL TSDLT FAYER LSHFR CELLR RGVQA QPLNV GFCEQ EFEQT |
| Synonyms: | TSD |
| Calculated MW: | 61kDa |
| Observed MW: | Refer to figures |
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