Description
Product Name: | GRID2 Polyclonal Antibody |
Product Code: | CAB19314 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting, Immunofluorescence |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, IF/ICC, ELISA |
Key Applications: | Western blotting, Immunofluorescence |
Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
Positive Samples: | Mouse brian |
Cellular Location: | dendritic spine, glutamatergic synapse, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse |
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 900-1007 of human GRID2 (NP_001501.2). |
Sequence: | IDLTP LDIDT LPTRQ ALEQI SDFRN THITT TTFIP EQIQT LSRTL SAKAA SGFTF GNVPE HRTGP FRHRA PNGGF FRSPI KTMSS IPYQP TPTLG LNLGN DPDRG TSI |
Synonyms: | GluD2, SCAR18 |
Calculated MW: | 113kDa |
Observed MW: | 113kDa |