GRID2 Polyclonal Antibody
- SKU:
- CAB19314
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | GRID2 Polyclonal Antibody |
| Product Code: | CAB19314 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brian |
| Cellular Location: | dendritic spine, glutamatergic synapse, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse |
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 900-1007 of human GRID2 (NP_001501.2). |
| Sequence: | IDLTP LDIDT LPTRQ ALEQI SDFRN THITT TTFIP EQIQT LSRTL SAKAA SGFTF GNVPE HRTGP FRHRA PNGGF FRSPI KTMSS IPYQP TPTLG LNLGN DPDRG TSI |
| Synonyms: | GluD2, SCAR18 |
| Calculated MW: | 113kDa |
| Observed MW: | 113kDa |
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