Description
Antibody Name: | GPR50 Antibody |
Antibody SKU: | PACO00877 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the Internal region of human GPR50. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | GPR50; Melatonin-related receptor; G protein-coupled receptor 50; H9 |
UniProt Protein Function: | GPR50: an orphan G protein coupled receptor with high sequence homology to the melatonin receptors MT1 and MT2. Does not bind melatonin. Forms heterodimers with MT1 and MT2 and acts as a negative regulator of MT1 agonist binding and G protein coupling; inhibition of melatonin receptor activity is dependent on the long, proline-rich carboxy terminal tail of GPR50. On a physiological level, GPR50 is involved in the regulation of adaptive thermoregulation in mammals and deletion of GPR50 in mice produces a profound effect on the response to fasting and facilitates entry into torpor. Polymorphisms in the corresponding GPR50 gene are associated with bipolar affective disorder and major depressive disorder in women, indicating that variation in GPR50 may be an important gender-specific risk factor for certain mental disorders. Belongs to the G-protein coupled receptor 1 family.Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-passChromosomal Location of Human Ortholog: Xq28Cellular Component: integral to plasma membraneMolecular Function: G-protein coupled receptor activity; identical protein binding; protein bindingBiological Process: cell surface receptor linked signal transduction; cell-cell signaling |
UniProt Protein Details: | |
NCBI Summary: | This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q13585 |
NCBI GenInfo Identifier: | 296439298 |
NCBI Gene ID: | 9248 |
NCBI Accession: | Q13585.3 |
UniProt Secondary Accession: | Q13585,Q0VGG3, Q3ZAR0 |
UniProt Related Accession: | Q13585 |
Molecular Weight: | 67,369 Da |
NCBI Full Name: | Melatonin-related receptor |
NCBI Synonym Full Names: | G protein-coupled receptor 50 |
NCBI Official Symbol: | GPR50 |
NCBI Official Synonym Symbols: | H9; Mel1c |
NCBI Protein Information: | melatonin-related receptor |
UniProt Protein Name: | Melatonin-related receptor |
UniProt Synonym Protein Names: | G protein-coupled receptor 50; H9 |
Protein Family: | Melatonin-related receptor |
UniProt Gene Name: | GPR50 |
UniProt Entry Name: | MTR1L_HUMAN |