Description
Product Name: | Glutamine Synthetase (GLUL) Monoclonal Antibody |
Product Code: | CAB21856 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting, Immunohistochemistry |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC0120 |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, IHC-P, ELISA |
Key Applications: | Western blotting, Immunohistochemistry |
Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:200 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Positive Samples: | Mouse kidney, Mouse liver, Mouse brain, Rat brain, Rat liver, Jurkat, HepG2, SH-SY5Y |
Cellular Location: | Cytoplasm, Mitochondrion |
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Glutamine Synthetase (GLUL) (P15104). |
Sequence: | AQWEF QIGPC EGISM GDHLW VARFI LHRVC EDFGV IATFD PKPIP GNWNG AGCHT NFSTK AMREE NGLKY IEEAI EKLSK RHQYH IRAYD PKGGL DNARR L |
Synonyms: | GS, GLNS, PIG43, PIG59 |
Calculated MW: | 42kDa |
Observed MW: | Refer to figures |