GDF15 Monoclonal Antibody
- SKU:
- CAB22097
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | GDF15 Monoclonal Antibody |
| Product Code: | CAB22097 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55565 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HT-1080+PMA/TPA |
| Cellular Location: | Secreted |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GDF15 (NP_004855.2). |
| Sequence: | HLHLR ISRAA LPEGL PEASR LHRAL FRLSP TASRS WDVTR PLRRQ LSLAR PQAPA LHLRL SPPPS QSDQL LAESS SARPQ LELHL RPQAA RGRRR ARARN G |
| Synonyms: | PDF, MIC1, PLAB, MIC-1, NAG-1, PTGFB, GDF-15 |
| Calculated MW: | 34kDa |
| Observed MW: | 15kDa/35kDa |
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