GCM2 Polyclonal Antibody
- SKU:
- CAB10656
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | GCM2 Polyclonal Antibody |
| Product Code: | CAB10656 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 287-506 of human GCM2 (NP_004743.1). |
| Sequence: | PYPTL YKDST SIPND TDWVH LNTLQ CNVNS YSSYE RSFDF TNKQH GWKPA LGKPS LVERT NHGQF QAMAT RPYYN PELPC RYLTT PPPGA PALQT VITTT TKVSY QAYQP PAMKY SDSVR EVKSL SSCNY APEDT GMSVY PEPWG PPVTV TRAAS PSGPP PMKIA GDCRA IRPTV AIPHE PVSSR TDEAE TWDVC LSGLG SAVSY SDRVG PFFTY NNEDF |
| Synonyms: | FIH2, GCMB, HRPT4, hGCMb |
| Calculated MW: | 57kDa |
| Observed MW: | Refer to figures |
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