Description
Product Name: | GADD45B Polyclonal Antibody |
Product Code: | CAB10650 |
Reactivity: | Human |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:500-1:2000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human GADD45B (NP_056490.2). |
Sequence: | MTLEE LVACD NAAQK MQTVT AAVEE LLVAA QRQDR LTVGV YESAK LMNVD PDSVV LCLLA IDEEE EDDIA LQIHF TLIQS FCCDN DINIV RVSGM QRLAQ LLGEP AETQG TTEAR DLHCL LVTNP HTDAW KSHGL VEVAS YCEES RGNNQ WVPYI SLQER |
Synonyms: | MYD118, GADD45BETA |
Calculated MW: | 18kDa |
Observed MW: | Refer to figures |