Antibody Name:	Flii Antibody (PACO41958)
Antibody SKU:	PACO41958
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Mouse
Immunogen:	Recombinant Mouse Protein flightless-1 homolog protein (495-827AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling By similarity. Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.

Synonyms:

Protein flightless-1 homolog, Flii, Fli1 Fliih

UniProt Protein Function:	FLI: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS). It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.Protein type: Nuclear receptor co-regulator; Actin-bindingCellular Component: brush border; cell junction; cytoplasm; cytoskeleton; microtubule organizing center; nucleoplasm; nucleusMolecular Function: actin binding; protein bindingBiological Process: actin cytoskeleton organization and biogenesis; actin filament severing; multicellular organismal development; regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:	This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
UniProt Code:	Q9JJ28
NCBI GenInfo Identifier:	11528490
NCBI Gene ID:	14248
NCBI Accession:	NP_071292.1
UniProt Secondary Accession:	Q9JJ28,Q8K095, Q8VI44
UniProt Related Accession:	Q9JJ28
Molecular Weight:	144,803 Da
NCBI Full Name:	protein flightless-1 homolog isoform 1
NCBI Synonym Full Names:	flightless I actin binding protein
NCBI Official Symbol:	Flii
NCBI Official Synonym Symbols:	Fliih; 3632430F08Rik
NCBI Protein Information:	protein flightless-1 homolog
UniProt Protein Name:	Protein flightless-1 homolog
UniProt Synonym Protein Names:
Protein Family:	Protein flightless
UniProt Gene Name:	Flii
UniProt Entry Name:	FLII_MOUSE