FGFR1 Monoclonal Antibody (CAB23390)
- SKU:
- CAB23390
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | FGFR1 Monoclonal Antibody |
Product Code: | CAB23390 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC53422 |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:2000-1:20000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Positive Samples: | U-251MG, Mouse brain, Rat brain |
Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic vesicle, Nucleus, Single-pass type I membrane protein, cytosol |
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 38-123 of human FGFR1 (NP_075598.2). |
Sequence: | GTGGA AGTGG AGTCC TTCCT GGTCC ACCCC GGTGA CCTGC TGCAG CTTCG CTGTC GGCTG CGGGA CGATG TGCAG AGCAT CAACT GGCTG CGGGA CGGGG TGCAG CTGGC GGAAA GCAAC CGCAC CCGCA TCACA GGGGA GGAGG TGGAG GTGCA GGACT CCGTG CCCGC AGACT CCGGC CTCTA TGCTT GCGTA ACCAG CAGCC CCTCG GGCAG TGACA CCACC TACTT CTCCG TCAAT GTTTC AGATG CTCTC CCC |
Synonyms: | CEK, FLG, HH2, OGD, ECCL, FLT2, KAL2, BFGFR, CD331, FGFBR, FLT-2, HBGFR, N-SAM, FGFR-1, HRTFDS, bFGF-R-1 |
Calculated MW: | 92kDa |
Observed MW: | 122kDa |