FADD Polyclonal Antibody
- SKU:
- CAB21699
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | FADD Polyclonal Antibody |
| Product Code: | CAB21699 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | A-431, Mouse small intestine, Rat small intestine |
| Cellular Location: | cytoplasm, cytosol, neuron projection, nucleus, plasma membrane, ripoptosome |
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1). |
| Sequence: | MDPFL VLLHS VSSSL SSSEL TELKF LCLGR VGKRK LERVQ SGLDL FSMLL EQNDL EPGHT ELLRE LLASL RRHDL LRRVD DFEAG AAAGA APGEE DLCAA FNVIC DNVGK DWRRL ARQLK VSDTK IDSIE DRYPR NLTER VRESL RIWKN TEKEN ATVAH LVGAL RSCQM NLVAD LVQEV QQARD LQNRS GAMSP MSWNS DASTS EAS |
| Synonyms: | GIG3, IMD90, MORT1 |
| Calculated MW: | 23kDa |
| Observed MW: | 27kDa |
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