FADD Monoclonal Antibody [PJ1D2AT] (CPAB0528)
![FADD Monoclonal Antibody [PJ1D2AT] (CPAB0528)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58749/63931/fadd-monoclonal-antibody-pj1d2at-cpab0528__66517__19754.1706535205.jpg?c=1 "FADD Monoclonal Antibody [PJ1D2AT] (CPAB0528)")
- SKU:
- CPAB0528
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Clone:
- PJ1D2AT
- Applications:
- WB
- Applications:
- ELISA
- Applications:
- IHC
![FADD Monoclonal Antibody [PJ1D2AT] (CPAB0528)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58749/63931/fadd-monoclonal-antibody-pj1d2at-cpab0528__66517__19754.1706535205.jpg?c=1&imbypass=on "FADD Monoclonal Antibody [PJ1D2AT] (CPAB0528)")
Description
system_update_alt Datasheet
| Product Name: | FADD Antibody |
| Product Sku: | CPAB0528 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human FADD mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human FADD amino acids 1-28 purified from Ecoli. |
| Clone: | PJ1D2AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA, Immunohistochemistry |
| Purification Method: | FADD antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2b |
| Background: | FADD is an adaptor protein that cooperates with a variety of cell surface receptors and mediates cell apoptotic signals. Using its C-terminal death domain, FADD is recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and consequently it take parts in the death signaling initiated by these receptors. FADD interaction with the receptors reviels the N-terminal effector domain of, which allows it to recruit caspase-8, and thus initiate the cysteine protease cascade. Knockout studies in mice furthermore propose the significance of FADD in premature T cell development. FADD plays a role in survival/proliferation and cell cycle development. FADD also takes part in cellular sublocalization, protein phosphorylation, and inhibitory molecules. |
| Synonyms: | GIG3, MORT1, MGC8528, FADD, Fas (TNFRSF6)-associated via death domain, Protein FADD, FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Growth-inhibiting gene 3 protein. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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