Name: Eotaxin-1 monoclonal antibody (AGIM0014)
SKU: AGIM0014
Availability: OutOfStock

Eotaxin-1 monoclonal antibody (AGIM0014)

(No reviews yet) Write a Review

SKU:

AGIM0014

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

hEOT1

Conjugation:

Unconjugated

Applications:

Description
0 Reviews

Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Storage conditions:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:	P51671
Background:	Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN- ?? timulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions.

UniProt Protein Function:	CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17q12 Cellular Component: extracellular region; extracellular space; intracellular Molecular Function:CCR chemokine receptor binding; chemokine activity; protein binding Biological Process: actin filament organization; cell adhesion; cellular calcium ion homeostasis; chemotaxis; chronic inflammatory response; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
NCBI Summary:	This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
UniProt Code:	P51671
NCBI GenInfo Identifier:	1706661
NCBI Gene ID:	6356
NCBI Accession:	P51671.1
UniProt Secondary Accession:	P51671,P50877, Q92490, Q92491,
UniProt Related Accession:	P51671
Molecular Weight:	10,732 Da
NCBI Full Name:	Eotaxin
NCBI Synonym Full Names:	C-C motif chemokine ligand 11
NCBI Official Symbol:	CCL11
NCBI Official Synonym Symbols:	SCYA11
NCBI Protein Information:	eotaxin
UniProt Protein Name:	Eotaxin
UniProt Synonym Protein Names:	C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Protein Family:	Eotaxin
UniProt Gene Name:	CCL11
UniProt Entry Name:	CCL11_HUMAN