EIF4G2/p97 Monoclonal Antibody (CAB21193)
- SKU:
- CAB21193
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
Description
| Product Name: | EIF4G2/p97 Monoclonal Antibody |
| Product Code: | CAB21193 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52820 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IP 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, HeLa, C2C12, Mouse brain, Rat lung |
| Cellular Location: | adherens junction, cytosol, eukaryotic translation initiation factor 4F complex |
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-490 of human EIF4G2/p97 (NP_001409.3). |
| Sequence: | PKTIN QIRQD AVKDL GVFIP APMAQ GMRSD FFLEG PFMPP RMKMD RDPLG GLADM FGQMP GSGIG TGPGV IQDRF SPTMG RHRSN QLFNG HGGHI MPPTQ SQFGE MGGKF MKSQG LSQLY HNQSQ GLLSQ LQGQS KDMPP RFSKK GQLNA DEISL RPAQS FLMNK NQVPK L |
| Synonyms: | P97, AAG1, DAP5, NAT1 |
| Calculated MW: | 102kDa |
| Observed MW: | 97kDa |
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