eIF4EBP1 Polyclonal Antibody

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SKU:
CAB21386
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF

Description

Product Name:eIF4EBP1 Polyclonal Antibody
Product Code:CAB21386
Reactivity:Human
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500-1:2000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location:cytoplasm, cytosol

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-118 of human eIF4EBP1. (NP_004086.1).
Sequence:TRIIY DRKFL MECRN SPVTK TPPRD LPTIP GVTSP SSDEP PMEAS QSHLR NSPED KRAGG EESQF EMDI
Synonyms:BP-1, 4EBP1, 4E-BP1, PHAS-I
Calculated MW:13kDa
Observed MW:Refer to figures
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