Description
Product Name: | eIF2α Monoclonal Antibody |
Product Code: | CAB21221 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting, Immunofluorescence |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC52379 |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, IF/ICC, ELISA |
Key Applications: | Western blotting, Immunofluorescence |
Recommended Dilution: | WB 1:2000-1:4000, IF/ICC 1:100-1:500 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Positive Samples: | HeLa, MCF7, 293F, NIH/3T3, Rat testis, PC-12 |
Cellular Location: | Cytoplasm, Stress granule |
Customer Validation: | WB(Homo sapiens) IF(Homo sapiens) |
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-315 of human eIF2α (NP_004085.1). |
Sequence: | MPGLS CRFYQ HKFPE VEDVV MVNVR SIAEM GAYVS LLEYN NIEGM ILLSE LSRRR IRSIN KLIRI GRNEC VVVIR VDKEK GYIDL SKRRV SPEEA IKCED KFTKS KTVYS ILRHV AEVLE YTKDE QLESL FQRTA WVFDD KYKRP GYGAY DAFKH AVSDP SILDS LDLNE DEREV LINNI NRRLT PQAVK IRADI EVACY GYEGI DAVKE ALRAG LNCST ENMPI KINLI APPRY VMTTT TLERT EGLSV LSQAM AVIKE KIEEK RGVFN VQMEP KVVTD TDETE LARQM ERLER ENAEV DGDDD AEEME AKAED |
Synonyms: | EIF2, EIF-2, EIF2A, EIF-2A, EIF-2alpha |
Calculated MW: | 36kDa |
Observed MW: | 38kDa |