EGFR Polyclonal Antibody (CAB21740)
- SKU:
- CAB21740
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | EGFR Polyclonal Antibody |
| Product Code: | CAB21740 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa |
| Cellular Location: | Cell membrane, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus membrane, Nucleus membrane, Nucleus, Secreted, Single-pass type I membrane protein |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human EGFR (NP_005219.2). |
| Sequence: | SINAT NIKHF KNCTS ISGDL HILPV AFRGD SFTHT PPLDP QELDI LKTVK EITGF LLIQA WPENR TDLHA FENLE IIRGR TKQHG QFSLA VVSLN ITSLG L |
| Synonyms: | ERBB, ERRP, HER1, mENA, ERBB1, PIG61, NISBD2 |
| Calculated MW: | 134kDa |
| Observed MW: | 175kDa |
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