EDNRB/Endothelin B Receptor Recombinant Protein (RPES3856)
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Description
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EDNRB/Endothelin B Receptor Recombinant Protein
The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. Low EDNRB expression played a role in the progression of ACC tumors. The autosomal recessive mutation in EDNRB may underlie a part of WS1 with the current diagnostic criteria, and supported that Hirschsprung's disease is a multifactorial genetic disease which requires additional factors.
| Product Name: | EDNRB/Endothelin B Receptor Recombinant Protein (RPES3856) |
| Product Code: | RPES3856 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | ABCDS,ET-B,ET-BR,ETB,ETBR,ETRB,HSCR,HSCR2,WS4A |
| Accession: | NP_000106.1 |
| Sequence: | Met 1-Lys101 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human EDNRB (NP_000106.1) (Met1-Lys101) was expressed with the Fc region of mouse IgG1 at the C-terminus. |
| Purity: | > 85 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 34.4 kDa |
| AP Mol Mass: | 47.5 and 43.7 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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