DR4 Monoclonal Antibody
- SKU:
- CAB24703
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- FC
Description
| Product Name: | DR4 Monoclonal Antibody |
| Product Code: | CAB24703 |
| Reactivity: | human |
| Applications: | Flow Cytometry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC63581 |
| Reactivity: | human |
| Tested Applications: | FC, ELISA |
| Key Applications: | Flow Cytometry |
| Recommended Dilution: | FC 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Membrane, single-pass type I membrane protein |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 124-232 of human DR4 (NP_003835.3). |
| Sequence: | EHSPL GELCP PGSHR SEHPG ACNRC TEGVG YTNAS NNLFA CLPCT ACKSD EEERS PCTTT RNTAC QCKPG TFRND NSAEM CRKCS RGCPR GMVKV KDCTP WSDIE CVHK |
| Synonyms: | TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, TNF receptor superfamily member 10a |
| Calculated MW: | 50kDa |
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