Desmocollin 3 Polyclonal Antibody
- SKU:
- CAB22232
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Desmocollin 3 Polyclonal Antibody |
| Product Code: | CAB22232 |
| Reactivity: | Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Rat thymus |
| Cellular Location: | cell junction, cell-cell junction, cytoplasm, desmosome, extracellular region, plasma membrane |
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 576-690 of human Desmocollin 3 (NP_001932.2). |
| Sequence: | EILQE YVVIC KPKMG YTDIL AVDPD EPVHG APFYF SLPNT SPEIS RLWSL TKVND TAARL SYQKN AGFQE YTIPI TVKDR AGQAA TKLLR VNLCE CTHPT QCRAT SRSTG VILGK |
| Synonyms: | DSC, DSC1, DSC2, DSC4, CDHF3, HT-CP |
| Calculated MW: | 100kDa |
| Observed MW: | 102kDa |
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