DDB2 Polyclonal Antibody
- SKU:
- CAB21374
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | DDB2 Polyclonal Antibody |
| Product Code: | CAB21374 |
| Reactivity: | Human |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | IF/ICC, ELISA |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-315 of human DDB2 (NP_000098.1). |
| Sequence: | MAPKK RPETQ KTSEI VLRPR NKRSR SPLEL EPEAK KLCAK GSGPS RRCDS DCLWV GLAGP QILPP CRSIV RTLHQ HKLGR ASWPS VQQGL QQSFL HTLDS YRILQ KAAPF DRRAT SLAWH PTHPS TVAVG SKGGD IMLWN FGIKD KPTFI KGIGA GGSIT GLKFN PLNTN QFYAS SMEGT TRLQD FKGNI LRVFA SSDTI NIWFC SLDVS ASSRM VVTGD NVGNV ILLNM DGKEL WNLRM HKKKV THVAL NPCCD WFLAT ASVDQ TVKIW DLRQV RGKAS FLYSL PHRHP VNAAC FSPDG ARLLT TDQKS EIRVY |
| Synonyms: | XPE, DDBB, UV-DDB2 |
| Calculated MW: | 48kDa |
| Observed MW: | Refer to figures |
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