Cynomolgus TIM-3/HAVCR2 Recombinant Protein (RPES2738)
- SKU:
- RPES2738
- Product Type:
- Recombinant Protein
- Species:
- Monkey
Description
Cynomolgus TIM-3/HAVCR2 Recombinant Protein
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
| Product Name: | Cynomolgus TIM-3/HAVCR2 Recombinant Protein (RPES2738) |
| Product Code: | RPES2738 |
| Size: | 10µg |
| Species: | Cynomolgus |
| Expressed Host: | Human Cells |
| Synonyms: | T cell immunoglobulin and mucin domain3, HAVCR2, Tim-3, TIM3 |
| Accession: | G7P6Q7 |
| Sequence: | Ser22-Arg201 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Cynomolgus TIM-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg201 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 46.3 kDa |
| AP Mol Mass: | 55-75 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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