Cynomolgus LAG-3/CD223 Recombinant Protein (RPES2592)
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- SKU:
- RPES2592
- Product Type:
- Recombinant Protein
- Species:
- Monkey
Description
system_update_altDatasheet
Cynomolgus LAG-3/CD223 Recombinant Protein
Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
| Product Name: | Cynomolgus LAG-3/CD223 Recombinant Protein (RPES2592) |
| Product Code: | RPES2592 |
| Size: | 10µg |
| Species: | Cynomolgus |
| Expressed Host: | Human Cells |
| Synonyms: | Lymphocyte activation gene 3 protein,LAG3,LAG-3,Protein FDC,CD223 |
| Accession: | XP_005570011.1 |
| Sequence: | Ala18-His449(Pro74) |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Cynomolgus LAG-3 Protein is produced by our Mammalian expression system and the target gene encoding Ala18-His449(Pro74) is expressed with a Fc tag at the C-terminus. |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
| Mol Mass: | 73.6 kDa |
| AP Mol Mass: | 90 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution ofPBS, pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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