CSTB Monoclonal Antibody [P2F1AT] (CPAB0524)
![CSTB Monoclonal Antibody [P2F1AT] (CPAB0524)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58745/63927/cstb-monoclonal-antibody-p2f1at-cpab0524__64230__10235.1706535203.jpg?c=1 "CSTB Monoclonal Antibody [P2F1AT] (CPAB0524)")
- SKU:
- CPAB0524
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Clone:
- P2F1AT
- Applications:
- WB
- Applications:
- ELISA
![CSTB Monoclonal Antibody [P2F1AT] (CPAB0524)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58745/63927/cstb-monoclonal-antibody-p2f1at-cpab0524__64230__10235.1706535203.jpg?c=1&imbypass=on "CSTB Monoclonal Antibody [P2F1AT] (CPAB0524)")
Description
system_update_alt Datasheet
| Product Name: | CSTB Antibody |
| Product Sku: | CPAB0524 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human CSTB mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CSTB amino acids 1-98 purified from Ecoli. |
| Clone: | P2F1AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA |
| Purification Method: | CSTB antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2b |
| Background: | Type 1 cystatins are also called stefins which function as intracellular thiol protease inhibitors. Cystatin-B protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. CSTB protein protects proteases leakage from lysosomes. Mutations in Stefin-B gene cause primary defects in patients with progressive myoclonic epilepsy (EPM1), a degenerative disease of the central nervous system. CSTB is overexpressed & elevated in the serum of HCC patients. Cystatin-B in vivo has a polymeric structure which is sensitive to the redox environment. Cystatin-B inhibits bone resorption by down-regulating intracellular cathepsin K activity despite increased osteoclast survival. Protein and mRNA levels of stefin B are significantly lower in atypical benign meningiomas. Stefins-A & Stefin-B which belong to the type-1 Cystatins, are up-regulated in lung tumours and thus able to counteract harmful tumour-associated proteolytic activity. |
| Synonyms: | Cystatin-B, Stefin-B, Liver thiol proteinase inhibitor, CPI-B, CSTB, CST6, EPM1, PME, STFB. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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