CRABP1 Monoclonal Antibody [PAT1A1AT] (CPAB0545)
![CRABP1 Monoclonal Antibody [PAT1A1AT] (CPAB0545)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58766/63948/crabp1-monoclonal-antibody-pat1a1at-cpab0545__03417__19660.1706535210.jpg?c=1 "CRABP1 Monoclonal Antibody [PAT1A1AT] (CPAB0545)")
- SKU:
- CPAB0545
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Clone:
- PAT1A1AT
- Applications:
- WB
- Applications:
- ELISA
![CRABP1 Monoclonal Antibody [PAT1A1AT] (CPAB0545)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58766/63948/crabp1-monoclonal-antibody-pat1a1at-cpab0545__03417__19660.1706535210.jpg?c=1&imbypass=on "CRABP1 Monoclonal Antibody [PAT1A1AT] (CPAB0545)")
Description
system_update_alt Datasheet
| Product Name: | CRABP1 Antibody |
| Product Sku: | CPAB0545 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human CRABP1 mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CRABP1 amino acids 1-137 purified from Ecoli. |
| Clone: | PAT1A1AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA |
| Purification Method: | CRABP1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2b |
| Background: | CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation and proliferation processes. Though, CRABP1 is structurally similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed and is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior. Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore, frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma. |
| Synonyms: | Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I, CRABP1, RBP5, CRABP, CRABPI. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
Related Products
![YWHAQ Monoclonal Antibody [PAT1A1AT] (CPAB0145)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58371/63553/ywhaq-monoclonal-antibody-pat1a1at-cpab0145__44252__12044.1706534988.jpg?c=1 "YWHAQ Monoclonal Antibody [PAT1A1AT] (CPAB0145)")
Anti-CRABP1 Antibody (CAB5434)
OverviewProduct Name:CRABP1 Rabbit mAbProduct Code:CAB5434Size:20uL, 50uL, 100uLSynonyms:CRABP, CRABP-I, CRABPI, RBP5A
SPAM1 Monoclonal Antibody
OverviewProduct Name:SPAM1 Monoclonal AntibodyProduct Code:CAB22178Reactivity:Human, Mouse, RatApplications:Western blotting, Imm
PMS2 Monoclonal Antibody
OverviewProduct Name:PMS2 Monoclonal AntibodyProduct Code:CAB22350Reactivity:HumanApplications:Western blotting