Description
Antibody Name: | CNGA1 Antibody (PACO61298) |
Antibody SKU: | PACO61298 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human cGMP-gated cation channel alpha-1 protein (586-690AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of HepG2 cells with PACO61298 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. |
Synonyms: | cGMP-gated cation channel alpha-1, Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cGMP-gated channel subunit alpha, CNGA1, CNCG, CNCG1 |
UniProt Protein Function: | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator. |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
UniProt Code: | P29973 |
NCBI GenInfo Identifier: | 71143141 |
NCBI Gene ID: | 1259 |
NCBI Accession: | NP_000078.2 |
UniProt Secondary Accession: | P29973,Q16279, Q16485, Q4W5E3, A8K7K6, J3KPZ2 |
UniProt Related Accession: | P29973 |
Molecular Weight: | 86,900 Da |
NCBI Full Name: | cGMP-gated cation channel alpha-1 isoform 2 |
NCBI Synonym Full Names: | cyclic nucleotide gated channel alpha 1 |
NCBI Official Symbol: | CNGA1 |
NCBI Official Synonym Symbols: | CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha |
NCBI Protein Information: | cGMP-gated cation channel alpha-1 |
UniProt Protein Name: | cGMP-gated cation channel alpha-1 |
UniProt Synonym Protein Names: | Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha |
Protein Family: | cGMP-gated cation channel |
UniProt Gene Name: | CNGA1 |
UniProt Entry Name: |
Antibodies |
CNGA1 Antibody (PACO02465) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |