Anti-CNGA1 Antibody (PACO61298)

Name: CNGA1 Antibody (PACO61298)
SKU: PACO61298
Availability: OutOfStock

Antibody Name:	CNGA1 Antibody (PACO61298)
Antibody SKU:	PACO61298
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human cGMP-gated cation channel alpha-1 protein (586-690AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Immunofluorescence staining of HepG2 cells with PACO61298 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Background:	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Synonyms:	cGMP-gated cation channel alpha-1, Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cGMP-gated channel subunit alpha, CNGA1, CNCG, CNCG1

UniProt Protein Function:	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Code:	P29973
NCBI GenInfo Identifier:	71143141
NCBI Gene ID:	1259
NCBI Accession:	NP_000078.2
UniProt Secondary Accession:	P29973,Q16279, Q16485, Q4W5E3, A8K7K6, J3KPZ2
UniProt Related Accession:	P29973
Molecular Weight:	86,900 Da
NCBI Full Name:	cGMP-gated cation channel alpha-1 isoform 2
NCBI Synonym Full Names:	cyclic nucleotide gated channel alpha 1
NCBI Official Symbol:	CNGA1
NCBI Official Synonym Symbols:	CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha
NCBI Protein Information:	cGMP-gated cation channel alpha-1
UniProt Protein Name:	cGMP-gated cation channel alpha-1
UniProt Synonym Protein Names:	Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
Protein Family:	cGMP-gated cation channel
UniProt Gene Name:	CNGA1
UniProt Entry Name: