Clusterin Monoclonal Antibody [P1A11AT] (CPAB0061)
![Clusterin Monoclonal Antibody [P1A11AT] (CPAB0061)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58290/63472/assay-genie-box-4__28632.1706534960.jpg?c=1 "Clusterin Monoclonal Antibody [P1A11AT] (CPAB0061)")
- SKU:
- CPAB0061
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- P1A11AT
- Applications:
- WB
- Applications:
- ELISA
- Applications:
- IHC
![Clusterin Monoclonal Antibody [P1A11AT] (CPAB0061)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58290/63472/assay-genie-box-4__28632.1706534960.jpg?c=1&imbypass=on "Clusterin Monoclonal Antibody [P1A11AT] (CPAB0061)")
Description
system_update_alt Datasheet
| Product Name: | Clusterin Antibody |
| Product Sku: | CPAB0061 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human Clusterin mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human Clusterin amino acids 1-333 purified from Ecoli. |
| Clone: | P1A11AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA, Immunohistochemistry |
| Purification Method: | Clusterin antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG1 |
| Background: | Clusterin also named Apolipoprotein J (APO-J) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the ? and ? chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil ? -helices and three predicted amphipathic a-helices. Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, b |
| Synonyms: | CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, MGC24903, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, NA1/NA2, Apolipoprotein J, Apo-J, Testosterone-repressed prostate message 2, TRPM-2. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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