Name: CELSR3 Antibody (PACO23311)
SKU: PACO23311
Availability: OutOfStock

Antibody Name:	CELSR3 Antibody (PACO23311)
Antibody SKU:	PACO23311
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:50-1:100, IF:1:100-1:500
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human CELSR3.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemistry analysis of paraffin-embedded human brain tissue using CELSR3 antibody.
	Immunofluorescence analysis of HepG2 cells, using CELSR3 antibody.

Background:	Receptor that may have an important role in cell/cell signaling during nervous system formation.
Synonyms:	Cadherin EGF LAG seven-pass G-type receptor 3 ; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains 2; Epidermal growth factor-like 1

UniProt Protein Function:	CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21.31Cellular Component: plasma membrane; integral to membraneMolecular Function: G-protein coupled receptor activity; protein binding; calcium ion bindingBiological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; neuron migration; axonal fasciculation; cilium biogenesis; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:	This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
UniProt Code:	Q9NYQ7
NCBI GenInfo Identifier:	145309304
NCBI Gene ID:	1951
NCBI Accession:	NP_001398.2
UniProt Secondary Accession:	Q9NYQ7,O75092
UniProt Related Accession:	Q9NYQ7
Molecular Weight:	Predicted Molecular Mass: 29.6kDaAccurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions.
NCBI Full Name:	cadherin EGF LAG seven-pass G-type receptor 3
NCBI Synonym Full Names:	cadherin, EGF LAG seven-pass G-type receptor 3
NCBI Official Symbol:	CELSR3
NCBI Official Synonym Symbols:	FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1
NCBI Protein Information:	cadherin EGF LAG seven-pass G-type receptor 3
UniProt Protein Name:	Cadherin EGF LAG seven-pass G-type receptor 3
UniProt Synonym Protein Names:	Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains protein 2; Multiple EGF-like domains protein 2
Protein Family:	Cadherin EGF LAG seven-pass G-type receptor
UniProt Gene Name:	CELSR3
UniProt Entry Name:	CELR3_HUMAN