CEACAM1 Monoclonal Antibody
- SKU:
- CAB24012
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | CEACAM1 Monoclonal Antibody |
| Product Code: | CAB24012 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC63148 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Hep G2, A549 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to aminoacids 35-428 of human CEACAM1(NP_001703.2). |
| Sequence: | QLTTE SMPFN VAEGK EVLLL VHNLP QQLFG YSWYK GERVD GNRQI VGYAI GTQQA TPGPA NSGRE TIYPN ASLLI QNVTQ NDTGF YTLQV IKSDL VNEEA TGQFH VYPEL PKPSI SSNNS NPVED KDAVA FTCEP ETQDT TYLWW INNQS LPVSP RLQLS NGNRT LTLLS VTRND TGPYE CEIQN PVSAN RSDPV TLNVT YGPDT PTISP SDTYY RPGAN LSLSC YAASN PPAQY SWLIN GTFQQ STQEL FIPNI TVNNS GSYTC HANNS VTGCN RTTVK TIIVT ELSPV VAKPQ IKASK TTVTG DKDSV NLTCS TNDTG ISIRW FFKNQ SLPSS ERMKL SQGNT TLSIN PVKRE DAGTY WCEVF NPISK NQSDP IMLNV NYNAL PQENG LSPG |
| Synonyms: | BGP, BGP1, BGPI |
| Calculated MW: | 58kDa |
| Observed MW: | 50-180kDa |
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