CDC37 Monoclonal Antibody [PAT3G7AT] (CPAB0570)
![CDC37 Monoclonal Antibody [PAT3G7AT] (CPAB0570)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58791/63973/assay-genie-box-4__24602.1706535218.jpg?c=1 "CDC37 Monoclonal Antibody [PAT3G7AT] (CPAB0570)")
- SKU:
- CPAB0570
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- PAT3G7AT
- Applications:
- ELISA
- Applications:
- FC
![CDC37 Monoclonal Antibody [PAT3G7AT] (CPAB0570)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58791/63973/assay-genie-box-4__24602.1706535218.jpg?c=1&imbypass=on "CDC37 Monoclonal Antibody [PAT3G7AT] (CPAB0570)")
Description
system_update_alt Datasheet
| Product Name: | CDC37 Antibody |
| Product Sku: | CPAB0570 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human CDC37 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CDC37 protein 1-378 amino acids purified from Ecoli. |
| Clone: | PAT3G7AT. |
| Reactivity: | Other bodies |
| Applications: | ELISA, Flow Cytometry |
| Purification Method: | CDC37 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. |
| Isotype: | IgG1 |
| Background: | CDC37 is an essential protein in Saccharomyces cerevisiae and is a molecular chaperone with precise function in cell signal transduction. CDC37 forms a complex/associates with Hsp90 molecular chaperone as one of several auxiliary proteins that are collectively referred to as Hsp90 co-chaperones. CDC37 also forms complex with a number of protein kinases such as CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. CDC34 is involved in directing Hsp90 to its target kinases. CDC37 up-regulation is a common early event in some localized human cancers. CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multitargeted therapies. CDC37 plays a role in regulating Hsp90 ATPase activity. CDC37 binds to Akt and HSP90 in the signal transduction pathway in human tumor cells. Tnf-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. CDC37 and heat shock protein 90 bind specifically to the kinase domain of LKB1. |
| Synonyms: | P50CDC37, CDC-37, CDC37, Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, CDC37A, Cell Division Cycle 37. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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