CD74 monoclonal antibody (FITC) (AGIM0154)
- SKU:
- AGIM0154
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- BU45
- Conjugation:
- FITC
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD74 monoclonal antibody (FITC) |
| Product Code: | AGIM0154 |
| Size: | 500 µL |
| Reactivity: | Human |
| Clone: | BU45 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P04233 |
| Background: | The BU45 epitop is a distinct determinant found distal from the C-terminus within the extracytoplasmatic domain of the CD74 antigen. It can be used to distinguish B cell lymphomas from T cell lymphomas. The different stages of B cell maturation are all positive with BU 45 including pre-B, ALL, B-CLL and Hairy Cell Leukaemia. Similary mononuclear Hodgkin and Reed-Sternburg cellls stain positive with anti CD 74 antibodies. In non-lymphoid neoplasia CD74 expression is seen in epithelial tumours such as adenocarcinoma of the uterus, transitional cell carcinoma of the bladder and lung squamous cell carcinoma. |
| UniProt Protein Function: | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. |
| NCBI Summary: | The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P04233 |
| NCBI GenInfo Identifier: | 20178292 |
| NCBI Gene ID: | 972 |
| NCBI Accession: | P04233.3 |
| UniProt Secondary Accession: | P04233,Q14597, Q29832, Q5U0J8, Q8SNA0, Q8WLP6, A8K7R1 B4DNE8, D3DQG3, D3DQG4, |
| UniProt Related Accession: | P04233 |
| Molecular Weight: | |
| NCBI Full Name: | HLA class II histocompatibility antigen gamma chain |
| NCBI Synonym Full Names: | CD74 molecule |
| NCBI Official Symbol: | CD74 |
| NCBI Official Synonym Symbols: | II; DHLAG; HLADG; Ia-GAMMA |
| NCBI Protein Information: | HLA class II histocompatibility antigen gamma chain |
| UniProt Protein Name: | HLA class II histocompatibility antigen gamma chain |
| UniProt Synonym Protein Names: | HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD_antigen: CD74 |
| Protein Family: | H-2 class II histocompatibility antigen |
| UniProt Gene Name: | CD74 |
| UniProt Entry Name: | HG2A_HUMAN |
Related Products
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