Name: CD69 monoclonal antibody (APC) (AGIM0483)
SKU: AGIM0483
Availability: OutOfStock

CD69 monoclonal antibody (APC) (AGIM0483)

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SKU:

AGIM0483

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1/kappa

Clone:

FN50

Conjugation:

APC

Applications:

Description
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Description

Datasheet

Isotype:	IgG1/kappa
Host Species:	Mouse
Storage:	Store at 4°C. Avoid prolonged exposure to light.
Uniprot:	Q07108
Background:	CD69 (C-type lectin domain family 2 C, CLEC2C, also known as AIM) is one of the earliest inducible cell surface molecules acquired during leukocyte activation. This glycoprotein serves as a lectin-type receptor in lymphocytes, NK cells and platelets; it is involved in lymphocyte proliferation. CD69 expression is counteracted on T cells in the AIDS stage of HIV infection, and may be also predictive for clinical response to chemoimmunotherapy.

UniProt Protein Function:	Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
UniProt Protein Details:	Subunit structure: Homodimer; disulfide-linked. Ref.6 Ref.7 Ref.8 Subcellular location: Membrane; Single-pass type II membrane protein. Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation. Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells. Post-translational modification: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes. Sequence similarities: Contains 1 C-type lectin domain.
NCBI Summary:	This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
UniProt Code:	Q07108
NCBI GenInfo Identifier:	584906
NCBI Gene ID:	969
NCBI Accession:	Q07108.1
UniProt Related Accession:	Q07108
Molecular Weight:	22,559 Da
NCBI Full Name:	Early activation antigen CD69
NCBI Synonym Full Names:	CD69 molecule
NCBI Official Symbol:	CD69
NCBI Official Synonym Symbols:	AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26
NCBI Protein Information:	early activation antigen CD69; leukocyte surface antigen Leu-23; early T-cell activation antigen p60; early lymphocyte activation antigen; activation inducer molecule (AIM/CD69); C-type lectin domain family 2, member C; CD69 antigen (p60, early T-cell act
UniProt Protein Name:	Early activation antigen CD69
UniProt Synonym Protein Names:	Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3
UniProt Gene Name:	CD69
UniProt Entry Name:	CD69_HUMAN