CD66c (CEACAM6) monoclonal antibody (AGIM0183)

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AGIM0183

Description

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Product Name:CD66c (CEACAM6) monoclonal antibody
Product Code:AGIM0183
Size:100 µg in 100 µL
Reactivity:Human
Clone:1H7-4B
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1 kappa
Host Species:Mouse
Storage:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles
Uniprot:P40199
Background:CD66c, also known as CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6) is a glycosyl phosphatidyl inositol- (GPI-) anchored glycoprotein. CEACAM and related genes make up the CEA family belonging to the immunoglobulin superfamily. CD66c is involved in cell adhesion. Additionally it serves as pathogen receptor (e.g. Helicobacter pylori, Neisseria, Moraxella, Candida albicans). Immunologically CEACAMs are characterized as members of the CD66 cluster of differentiation. Antibodies against CEACAM6 are commonly used in immunohistochemistry to identify cells expressing the glycoprotein in tissue samples and granulocytes. However, CEACAM6 is also found in serum where it can be used as a tumor marker. In adults CEACAM6 is primarily expressed in epithelia of the gastrointestinal tissue, often together with CEACAM1, CEACAM6 and CEACAM7. In granulocytes CEACAM6 is co-expressed with CEACAM1, CEACAM3 and CEACAM8. Most CEACAM6 antibodies tend to have some degree of cross-reactivity with other CEACAMs but 1H7-4B binds exclusively to CEACAM6.
UniProt Protein Function:CEACAM6: Belongs to the immunoglobulin superfamily. CEA family
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: cell-cell signaling; leukocyte migration; signal transduction

NCBI Summary:This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
UniProt Code:P40199
NCBI GenInfo Identifier:296439410
NCBI Gene ID:4680
NCBI Accession:P40199.3
UniProt Secondary Accession:P40199,Q13774, Q14920, Q53XP7,
UniProt Related Accession:P40199
Molecular Weight:37,195 Da
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 6
NCBI Synonym Full Names:carcinoembryonic antigen related cell adhesion molecule 6
NCBI Official Symbol:CEACAM6  
NCBI Official Synonym Symbols:NCA; CEAL; CD66c  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 6
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 6
UniProt Synonym Protein Names:Non-specific crossreacting antigen; Normal cross-reacting antigen; CD_antigen: CD66c
Protein Family:Carcinoembryonic antigen-related cell adhesion molecule
UniProt Gene Name:CEACAM6  
UniProt Entry Name:CEAM6_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1 kappa
Clone:
1H7-4B
Conjugation:
Unconjugated
Applications:
FC
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