CD58 monoclonal antibody (AGIM0051)
- SKU:
- AGIM0051
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- MEM-63
- Conjugation:
- Unconjugated
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD58 monoclonal antibody |
| Product Code: | AGIM0051 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human, Porcine |
| Clone: | MEM-63 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4 C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | P19256 |
| Background: | CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by both hematopoietic and non-hematopoietic cells (often on antigen presenting cells) and serving as ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 is expressed in transmembrane form and in GPI-anchored form; the later is constitutively associated with protein kinases whereas the transmembrane form activates kinase activity upon triggering. CD58 is a powerful tool for detection of minimal residual disease in acute lymphocytic leukemia, and for evaluation of liver damage related with hepatitis B. |
| UniProt Protein Function: | Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. |
| NCBI Summary: | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] |
| UniProt Code: | P19256 |
| NCBI GenInfo Identifier: | 126225 |
| NCBI Gene ID: | 965 |
| NCBI Accession: | P19256.1 |
| UniProt Secondary Accession: | P19256,Q5U053, Q6IB65, Q96KI9, A8K7G5, |
| UniProt Related Accession: | P19256 |
| Molecular Weight: | 27,960 Da |
| NCBI Full Name: | Lymphocyte function-associated antigen 3 |
| NCBI Synonym Full Names: | CD58 molecule |
| NCBI Official Symbol: | CD58 |
| NCBI Official Synonym Symbols: | ag3; LFA3; LFA-3 |
| NCBI Protein Information: | lymphocyte function-associated antigen 3 |
| UniProt Protein Name: | Lymphocyte function-associated antigen 3 |
| UniProt Synonym Protein Names: | Surface glycoprotein LFA-3; CD_antigen: CD58 |
| Protein Family: | Lymphocyte function-associated antigen |
| UniProt Gene Name: | CD58 |
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