CD5 monoclonal antibody (PE) (AGIM0340)

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SKU:
AGIM0340
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
LT1
Conjugation:
PE
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD5 monoclonal antibody (PE)
Product Code:AGIM0340
Size:100 µL
Reactivity:Human
Clone:LT1
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P06127
Background:In humans CD5 is a 67 kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibites strain dependent variation, and the phenotypic, anatomical, functional, pevelopmental, and phatological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
UniProt Protein Function:CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:protein binding; transmembrane receptor activity; receptor activity; scavenger receptor activity

Biological Process: cell proliferation; receptor-mediated endocytosis; T cell costimulation; cell recognition

UniProt Code:P06127
NCBI GenInfo Identifier:313104090
NCBI Gene ID:921
NCBI Accession:P06127.2
UniProt Secondary Accession:P06127,A0N0P4, A8K9I3,
UniProt Related Accession:P06127
Molecular Weight:459
NCBI Full Name:T-cell surface glycoprotein CD5
NCBI Synonym Full Names:CD5 molecule
NCBI Official Symbol:CD5  
NCBI Official Synonym Symbols:T1; LEU1  
NCBI Protein Information:T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1
UniProt Protein Name:T-cell surface glycoprotein CD5
UniProt Synonym Protein Names:Lymphocyte antigen T1/Leu-1; CD_antigen: CD5
Protein Family:CD5 antigen
UniProt Gene Name:CD5  
UniProt Entry Name:CD5_HUMAN
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