Name: CD5 monoclonal antibody (APC) (AGIM0455)
SKU: AGIM0455
Availability: OutOfStock

CD5 monoclonal antibody (APC) (AGIM0455)

(No reviews yet) Write a Review

SKU:

AGIM0455

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

HISM2

Conjugation:

APC

Applications:

Description

Isotype:	IgG1
Host Species:	Mouse
Storage:	Store at 4°C. Avoid prolonged exposure to light.
Uniprot:	P06127
Background:	CD5 antigen is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many Tcell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.

UniProt Protein Function:	CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains.
UniProt Protein Details:	Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; transmembrane receptor activity; receptor activity; scavenger receptor activity Biological Process: cell proliferation; receptor-mediated endocytosis; T cell costimulation; cell recognition
UniProt Code:	P06127
NCBI GenInfo Identifier:	313104090
NCBI Gene ID:	921
NCBI Accession:	P06127.2
UniProt Secondary Accession:	P06127,A0N0P4, A8K9I3,
UniProt Related Accession:	P06127
Molecular Weight:	459
NCBI Full Name:	T-cell surface glycoprotein CD5
NCBI Synonym Full Names:	CD5 molecule
NCBI Official Symbol:	CD5
NCBI Official Synonym Symbols:	T1; LEU1
NCBI Protein Information:	T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1
UniProt Protein Name:	T-cell surface glycoprotein CD5
UniProt Synonym Protein Names:	Lymphocyte antigen T1/Leu-1; CD_antigen: CD5
Protein Family:	CD5 antigen
UniProt Gene Name:	CD5
UniProt Entry Name:	CD5_HUMAN

View AllClose

0 Reviews

View AllClose