CD34 monoclonal antibody (AGIM0041)

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SKU:
AGIM0041
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
4H11[APG]
Conjugation:
Unconjugated
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD34 monoclonal antibody
Product Code:AGIM0041
Size:100 µg in 100 µL
Reactivity:Human
Clone:4H11[APG]
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:P28906
Background:CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. This material is offered for research only. Not for use in human. For in vitro use only. ImmunoTools will not be held responsible for patent infringement or other violations that may occur with the use of our products. .
UniProt Protein Function:CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: intercellular bridge; integral to plasma membrane; lysosome; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:sulfate binding; carbohydrate binding; transcription factor binding

Biological Process: positive regulation of odontogenesis; regulation of immune response; negative regulation of nitric oxide biosynthetic process; glomerular filtration; cell motility involved in cell locomotion; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-10 production; cell proliferation; cell-cell adhesion; positive regulation of angiogenesis; endothelial cell proliferation; regulation of blood pressure; tissue homeostasis; hemopoiesis; leukocyte migration

NCBI Summary:The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:P28906
NCBI GenInfo Identifier:3183511
NCBI Gene ID:947
NCBI Accession:P28906.2
UniProt Secondary Accession:P28906,Q15970, Q15971, Q5JTA3, Q5JTA4, Q9UJB1, A8K664
UniProt Related Accession:P28906
Molecular Weight:35,011 Da
NCBI Full Name:Hematopoietic progenitor cell antigen CD34
NCBI Synonym Full Names:CD34 molecule
NCBI Official Symbol:CD34  
NCBI Protein Information:hematopoietic progenitor cell antigen CD34; CD34 antigen
UniProt Protein Name:Hematopoietic progenitor cell antigen CD34
UniProt Synonym Protein Names:CD_antigen: CD34
Protein Family:Hematopoietic progenitor cell antigen
UniProt Gene Name:CD34  
UniProt Entry Name:CD34_HUMAN
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