CD222 monoclonal antibody (PE) (AGIM0097)
- SKU:
- AGIM0097
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- MEM-238
- Conjugation:
- PE
- Applications:
- FC
Description
| Product Name: | CD222 monoclonal antibody (PE) |
| Product Code: | AGIM0097 |
| Size: | 500 µL |
| Reactivity: | Human |
| Clone: | MEM-238 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P11717 |
| Background: | CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-??, last but not least CD222 serves as a receptor for heparanase and even for Listeria. |
| UniProt Protein Function: | IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Vesicle Chromosomal Location of Human Ortholog: 6q26 Cellular Component: cell surface; clathrin coat; early endosome; endocytic vesicle; endosome; extracellular space; focal adhesion; integral to plasma membrane; late endosome; lysosomal membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network transport vesicle Molecular Function:enzyme binding; G-protein alpha-subunit binding; G-protein coupled receptor activity; glycoprotein binding; identical protein binding; insulin-like growth factor II binding; insulin-like growth factor receptor activity; mannose binding; phosphoprotein binding; protein binding; receptor activity; retinoic acid binding; transporter activity Biological Process: G-protein coupled receptor protein signaling pathway; insulin-like growth factor receptor signaling pathway; liver development; organ regeneration; positive regulation of apoptosis; post-embryonic development; receptor-mediated endocytosis; response to retinoic acid; signal transduction; spermatogenesis Disease: Hepatocellular Carcinoma |
| NCBI Summary: | This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015] |
| UniProt Code: | P11717 |
| NCBI GenInfo Identifier: | 317373416 |
| NCBI Gene ID: | 3482 |
| NCBI Accession: | P11717.3 |
| UniProt Secondary Accession: | P11717,Q7Z7G9, Q96PT5, |
| UniProt Related Accession: | P11717 |
| Molecular Weight: | 274,375 Da |
| NCBI Full Name: | Cation-independent mannose-6-phosphate receptor |
| NCBI Synonym Full Names: | insulin like growth factor 2 receptor |
| NCBI Official Symbol: | IGF2R |
| NCBI Official Synonym Symbols: | MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R |
| NCBI Protein Information: | cation-independent mannose-6-phosphate receptor |
| UniProt Protein Name: | Cation-independent mannose-6-phosphate receptor |
| UniProt Synonym Protein Names: | 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD_antigen: CD222 |
| Protein Family: | Cation-independent mannose-6-phosphate receptor |
| UniProt Gene Name: | IGF2R |
| UniProt Entry Name: | MPRI_HUMAN |
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