Name: CD222 monoclonal antibody (AGIM0096)
SKU: AGIM0096
Availability: OutOfStock

CD222 monoclonal antibody (AGIM0096)

(No reviews yet) Write a Review

SKU:

AGIM0096

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

MEM-238

Conjugation:

Unconjugated

Applications:

Description
0 Reviews

Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:	P11717
Background:	CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-??, last but not least CD222 serves as a receptor for heparanase and even for Listeria.

UniProt Protein Function:	IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Receptor, misc.; Vesicle Chromosomal Location of Human Ortholog: 6q26 Cellular Component: cell surface; clathrin coat; early endosome; endocytic vesicle; endosome; extracellular space; focal adhesion; integral to plasma membrane; late endosome; lysosomal membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network transport vesicle Molecular Function:enzyme binding; G-protein alpha-subunit binding; G-protein coupled receptor activity; glycoprotein binding; identical protein binding; insulin-like growth factor II binding; insulin-like growth factor receptor activity; mannose binding; phosphoprotein binding; protein binding; receptor activity; retinoic acid binding; transporter activity Biological Process: G-protein coupled receptor protein signaling pathway; insulin-like growth factor receptor signaling pathway; liver development; organ regeneration; positive regulation of apoptosis; post-embryonic development; receptor-mediated endocytosis; response to retinoic acid; signal transduction; spermatogenesis Disease: Hepatocellular Carcinoma
NCBI Summary:	This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
UniProt Code:	P11717
NCBI GenInfo Identifier:	317373416
NCBI Gene ID:	3482
NCBI Accession:	P11717.3
UniProt Secondary Accession:	P11717,Q7Z7G9, Q96PT5,
UniProt Related Accession:	P11717
Molecular Weight:	274,375 Da
NCBI Full Name:	Cation-independent mannose-6-phosphate receptor
NCBI Synonym Full Names:	insulin like growth factor 2 receptor
NCBI Official Symbol:	IGF2R
NCBI Official Synonym Symbols:	MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R
NCBI Protein Information:	cation-independent mannose-6-phosphate receptor
UniProt Protein Name:	Cation-independent mannose-6-phosphate receptor
UniProt Synonym Protein Names:	300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD_antigen: CD222
Protein Family:	Cation-independent mannose-6-phosphate receptor
UniProt Gene Name:	IGF2R
UniProt Entry Name:	MPRI_HUMAN