Cd207 Antibody (PACO52594)
- SKU:
- PACO52594
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Cd207 Antibody (PACO52594) |
| Antibody SKU: | PACO52594 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse C-type lectin domain family 4 member K protein (63-331AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. |
| Synonyms: | C-type lectin domain family 4 member K (Langerin) (CD antigen CD207), Cd207, Clec4k |
| UniProt Protein Function: | langerin: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. Homotrimer. Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 6|6 C3Cellular Component: integral to plasma membraneMolecular Function: carbohydrate bindingBiological Process: defense response to virus |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8VBX4 |
| NCBI GenInfo Identifier: | 31560764 |
| NCBI Gene ID: | 246278 |
| NCBI Accession: | NP_659192.2 |
| UniProt Secondary Accession: | Q8VBX4,Q8R442 |
| UniProt Related Accession: | Q8VBX4 |
| Molecular Weight: | 37,621 Da |
| NCBI Full Name: | C-type lectin domain family 4 member K |
| NCBI Synonym Full Names: | CD207 antigen |
| NCBI Official Symbol: | Cd207 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | C-type lectin domain family 4 member K |
| UniProt Protein Name: | C-type lectin domain family 4 member K |
| UniProt Synonym Protein Names: | Langerin; CD_antigen: CD207 |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | Cd207 |
| UniProt Entry Name: |
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