CD20 monoclonal antibody (AGIM0034)

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SKU:
AGIM0034
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-97
Conjugation:
Unconjugated
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD20 monoclonal antibody
Product Code:AGIM0034
Size:100 µg in 100 µL
Reactivity:Human, Porcine, Bovine
Clone:MEM-97
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:P11836
Background:CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.
UniProt Protein Function:MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell surface; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function:epidermal growth factor receptor binding

Biological Process: B cell proliferation; humoral immune response

Disease: Immunodeficiency, Common Variable, 5

NCBI Summary:This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:P11836
NCBI GenInfo Identifier:115968
NCBI Gene ID:931
NCBI Accession:P11836.1
UniProt Related Accession:P11836
Molecular Weight:
NCBI Full Name:B-lymphocyte antigen CD20
NCBI Synonym Full Names:membrane spanning 4-domains A1
NCBI Official Symbol:MS4A1  
NCBI Official Synonym Symbols:B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16  
NCBI Protein Information:B-lymphocyte antigen CD20
UniProt Protein Name:B-lymphocyte antigen CD20
UniProt Synonym Protein Names:B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
Protein Family:CD209 antigen
UniProt Gene Name:MS4A1  
UniProt Entry Name:CD20_HUMAN
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