Description
system_update_altDatasheet
Product Name: | CD18 monoclonal antibody (FITC) |
Product Code: | AGIM0312 |
Size: | 100 µL |
Reactivity: | Human |
Clone: | HI18a |
Applications: | Flow Cytometry |
Conjugate: | FITC |
Isotype: | IgG1 |
Host Species: | Mouse |
Storage: | Store at 4°C. Avoid prolonged exposure to light. |
Uniprot: | P05107 |
Background: | CD18, integrin ??2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (??2) integrins: ?±L??2 (CD11a/CD18, LFA-1), ?±M??2 (CD11b/CD18, Mac-1, CR3), ?±X??2 (CD11c/CD18) and ?±D??2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. |