CD163 Polyclonal Antibody (CAB24841)
- SKU:
- CAB24841
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | CD163 Polyclonal Antibody |
| Product Code: | CAB24841 |
| Reactivity: | Human, Mouse |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | IF/ICC |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 810-1049 of human CD163(NP_004235.4). |
| Sequence: | HKEDA GVICS EFMSL RLTSE ASREA CAGRL EVFYN GAWGT VGKSS MSETT VGVVC RQLGC ADKGK INPAS LDKAM SIPMW VDNVQ CPKGP DTLWQ CPSSP WEKRL ASPSE ETWIT CDNKI RLQEG PTSCS GRVEI WHGGS WGTVC DDSWD LDDAQ VVCQQ LGCGP ALKAF KEAEF GQGTG PIWLN EVKCK GNESS LWDCP ARRWG HSECG HKEDA AVNCT DISVQ KTPQK ATTGR SSRQS |
| Synonyms: | CD163, M130, MM130, SCARI1, CD163 molecule |
| Calculated MW: | 121kDa/124kDa/125kDa |
| Observed MW: | Refer to figures |
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