CD163 Polyclonal Antibody (CAB23023)
- SKU:
- CAB23023
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | CD163 Polyclonal Antibody |
| Product Code: | CAB23023 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | 293T |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 42-261 of human CD163 (NP_004235.4?). |
| Sequence: | SSLGG TDKEL RLVDG ENKCS GRVEV KVQEE WGTVC NNGWS MEAVS VICNQ LGCPT AIKAP GWANS SAGSG RIWMD HVSCR GNESA LWDCK HDGWG KHSNC THQQD AGVTC SDGSN LEMRL TRGGN MCSGR IEIKF QGRWG TVCDD NFNID HASVI CRQLE CGSAV SFSGS SNFGE GSGPI WFDDL ICNGN ESALW NCKHQ GWGKH NCDHA EDAGV ICSKG |
| Synonyms: | M130, MM130, SCARI1 |
| Calculated MW: | 125kDa |
| Observed MW: | 160kDa |
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